Source: http://www.thehollywoodgossip.com/2013/01/amber-rose-baby-belly-stretch-mark-free/
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The National Weather Service in Peachtree City predicts showers and thunderstorms for the rest of the afternoon until around 5 p.m. The weather service warns that storms could be severe, with winds up to 30 miles per hour.?
High near 68. Chance of precipitation is 100 percent. New rainfall amounts between a quarter and half of an inch are possible.
Tonight, a?chance of showers and thunderstorms before 9 p.m., then a slight chance of showers between 9 p.m. and 10 p.m. Mostly cloudy, with a low around 33. Northwest wind 10 to 15 mph, with gusts as high as 25 mph. Chance of precipitation is 40 percent.
The National Weather Service in Peachtree City has issued a Tornado Warning for: extreme northwestern Cherokee County in north central Georgia Western Pickens County in north central Georgia Northern Bartow County in northwest Georgia East Central Floyd County in northwest Georgia Eastern Gordon County in northwest Georgia.
Until 11:45 am EST.
At 10:56 am EST, National Weather Service Doppler radar indicated a severe thunderstorm capable of producing a tornado 16 miles southwest of Kingston, moving northeast at 60 mph. Law enforcement have reported a funnel cloud and trees down with this storm.
Other locations in the warning include but are not limited to Adairsville.
Recommended actions
Heavy rainfall may obscure this tornado. Take cover now! If you wait to see or hear it coming, it will be too late to get to a safe place.
If You See wind damage, hail or flooding, wait until the Storm has passed, and then call the National Weather Service toll free at (866) 763-4466. You can also tweet your report using Hashtag Gawx. A Tornado Watch remains in effect until 4:00 pm EST Wednesday afternoon for northern Georgia.
Source: http://calhountimes.com/bookmark/21564088
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US Steel reported a smaller fourth-quarter loss as carmakers and other manufacturers used more steel, and it said shipments should rise in the current quarter.
The steel industry has been buffeted by an inconsistent global economy. On Monday, the U.S. Commerce Department reported that overall orders for durable goods rose 4.6 percent in December. But a key gauge of business investment plans rose just 0.2 percent.
"We continue to be challenged by uncertain global economic and steel market conditions," Chairman and CEO John P. Surma said.
The Pittsburgh-based steelmaker lost $50 million, or 35 cents per share for the most recent quarter. A year ago it lost $211 million, or $1.46 per share.
The most recent loss would have been 41 cents per share if not for a favorable settlement of a contract dispute. The result was much better than the loss of 70 cents per share expected by analysts surveyed by FactSet.
Revenue fell 6.9 percent to $4.49 billion. Analysts had been expecting revenue of $4.33 billion.
The biggest turnaround happened in flat-rolled steel, which is used for cars and heavy equipment. After an operating loss of $72 million a year ago, that segment turned in an $11 million profit in the most recent quarter. Shipments rose 3.7 percent to 3.9 million tons. The larger shipments helped offset a price decline of $20 per ton, to $721.
That helped offset a decline in profits from tubular steel, which is used more by the energy industry. Shipments declined 15.6 percent to 407,000 tons. Pricing fell 5 percent to $1,624 per ton. End users reduced drilling and delayed purchases, and tough competition from steel importers drove down prices, the company said.
For the first quarter, the company said it expects a slight improvement in its European and tubular segments. Tubular volume should pick up, but pricing will be lower.
Its flat-rolled segment will be near breakeven. Steel buyers in North America are still cautious. Spot orders are picking up slightly and spot pricing should rise, but those benefits may be offset by lower prices under long-term contracts, the company said.
For all of 2012, the company lost $124 million, or 86 cents per share. In 2011 it lost $53 million, or 37 cents per share. Revenue fell 2.8 percent to $19.33 billion.
Shares of Pittsburgh-based United States Steel Corp. fell 28 cents to $23.44 in early trading.
Source: http://news.yahoo.com/us-steel-shrinks-4q-loss-50m-131526121--finance.html
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TEHRAN, Iran - Iranian state TV says the country has successfully sent a monkey into space in what's described as another step toward Tehran's goal of a manned space flight.
Monday's report said the monkey was sent up in a Pishtam, or Explorer, rocket to a height of 120 kilometres.
It gave no other details on the timing or location of the launch, but said the monkey returned safely.
Iran has said it seeks to send an astronaut into space as part of its ambitious aerospace program.
In 2010, Iran said it launched a rocket into space carrying a mouse, turtle and worms.
The U.S. and its allies worry that technology from the space program could also be used to develop long-range missiles that could potentially be armed with nuclear warheads.
Source: http://news.yahoo.com/iranian-state-tv-says-country-successfully-sent-monkey-113831156.html
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The past year or so has seen a rush of companies moving toward REIT status.
Firms in wide-ranging industries including healthcare, timber companies, outdoor advertisers, casinos, data warehouses and digital transmission towers have converted, or will soon convert, into REITs.
In order to become a REIT, a company must fulfill two requirements:
First, it must invest at least 75% of its assets in real estate and get a minimum of 75% of its revenue from rents or other direct real-estate activities.
Second, it must pay out a minimum of 90% of its profits to its shareholders in the form of dividends.
If a company meets these criteria, the government (Internal Revenue Service) will not tax those profits at the company level. But as stated previously, the dividends received by shareholders are taxed as ordinary income.
Besides the tax advantages, there are other reasons as to why are companies are making the conversion to REIT status.
It seems to be a very successful strategy to increase share price performance, making both management and shareholders happy.
Jeff Kolitch, portfolio manager at Baron Real Estate Fund, told Barron's that the average REIT trades at 22 times adjusted funds from operations (AFFO), a measure comparable to operating cash flow. There are many, many stocks that trade below 22 times operating cash flow, so conversion to REIT status gives many stocks an immediate boost.
In addition, the newly-converted companies enjoy the access to large amounts of capital enjoyed by real estate trusts. Equity REITs last year raised more capital through stock and debt offerings than the industry had in at least 12 years. The amount raised last year was also as much capital raised as the prior five years combined, according to research firm SNL Financial.
This trend toward an expanding REIT universe is likely to continue in the months and years ahead.
Adam Markman, a managing director at real estate research firm Green Street Advisors, told Bloomberg News, "The pace of conversions isn't slowing. The more success that we have, the more likely it is we'll see additional activity."
Michael Fitzgerald, a partner at Paul Hastings, has worked on REIT conversions and is also a supporter of the REIT trend.
"This is just the beginning. There's going to be a huge emphasis on tax structuring starting in 2013," he told the Financial Times.
This "tax structuring" should expand the REIT universe even further.
For investors interested in income, some of the new "stars" in the REIT universe are rather intriguing.
The list includes: casino company Penn National Gaming Inc. (Nasdaq: PENN), communications infrastructure firms American Tower Corp. (NYSE: AMT) and SBA Communications Corp. (Nasdaq: SBAC), outdoor advertising company Lamar Advertising Co. (Nasdaq: LAMR), publisher Gannett Co. Inc. (NYSE: GCI), and data service companies Digital Realty Trust Inc. (NYSE: DLR) and DuPont Fabros Technology Inc. (NYSE: DFT).
Some of the above have already converted to a REIT, while others are still contemplating the move.
Other firms including CBS Corp. (NYSE: CBS) and Cincinnati Bell Inc. (NYSE: CBB) are spinning off part of their firm into a REIT. Cincinnati Bell has already done that with the spinoff its co-location business unit CyrusOne Inc. (Nasdaq: CONE). CBS is considering the spinoff of its billboard advertising unit as a REIT. That business accounted for about 10% of its operating profits.
If you're interested in investing in REITs in 2013, check out this latest offer from our Global Investing Strategist Martin Hutchinson, who has a winning strategy to find the best sources of yield.
Related Articles and News:
Source: http://moneymorning.com/2013/01/29/investing-in-2013-how-to-profit-from-the-expanding-reit-universe/
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Just as we saw with AT&T's Garnet Red Galaxy S III, Samsung has now introduced yet another device that's wrapped in a similar color scheme -- and, hey, with Valentine's Day just around the corner, what better time, right? The difference here, however, is the South Korean company's including a matching case as part of this special edition Galaxy Tab 2 7.0, with the newfangled bundle set to be available for $220 when it goes on sale this week. Additionally, Samsung's 7-inch Garnet Red Tab 2 will be shipping with Jelly Bean already onboard, while other internal specs won't be any different that the ones we became familiar with last year -- ones such as the 1,024 x 600 TFT display, 1GHz, dual-core TI OMAP CPU, 8GB of internal storage and, of course, that handy IR blaster. You'll have to snag one quick if you're interested, though, as Samsung has told us the blooming Tab 2 7.0 will -- much like other peculiar sets -- only be available for a limited time at shops like Amazon, Walmart, Office Depot, Tiger Direct, Fry's Electronics and Toys R Us.
Samsung Brings Color to the Tablet Space with Garnet Red Edition Galaxy Tab 2
Limited edition color offering is a blend of on-the-go portability and style - includes free matching case, runs Android Jelly Bean
RIDGEFIELD PARK, N.J., January 28, 2013 - Samsung Electronics America Inc., a market leader and award-winning innovator in consumer electronics, today announced that a new Garnet Red Edition of the powerful Galaxy Tab(R) 2 7.0 will be available for a limited time, beginning this week from participating retailers.
The new Galaxy Tab 2 7.0, preloaded with Android 4.1, Jelly Bean, showcases Samsung's commitment to providing users with choice, portability and entertainment. This limited edition version of the Galaxy Tab 2 7.0 is competitively priced at $219.99 and also includes a matching Garnet Red case ($50 value) at no additional cost.
A stylish choice perfect for Valentine's Day or any occasion
The Garnet Red Edition Galaxy Tab 2 was created for consumers who want to stay connected and entertained on-the-go, and are seeking a unique color offering.
"This new eye-catching version of the Galaxy Tab 2 offers endless entertainment in the palm of your hand, while the stylish Garnet Red look will set you apart from the crowd," said Michael Abary, Senior Vice President, Samsung Electronics America, Inc. "The Garnet Red version of the Galaxy(R) S III has been incredibly well-received, so we are happy to make the same brilliant color available for our Galaxy Tab 2 as well."
A compact 7" powerhouse that's smart and easy to use
The Galaxy Tab 2 is a powerful dual-core tablet running Android Jelly Bean, and features an easily accessible memory card slot for convenient loading of multimedia files in a range of supported file formats.
The tablet offer endless content access in a sleek design that can maximize the home entertainment experience. The Smart Remote App and built-in IR Blaster turns the Galaxy Tab 2 into a universal remote, helping users to easily find their favorite shows and change the channel directly from the tablet. Users can choose from hundreds of thousands of apps or access favorite movies and TV shows from Google Play or Media Hub.
The new Garnet Red Edition Galaxy Tab 2 will be available while supplies last, from Walmart, Amazon.com, Office Depot, Fry's, Tiger Direct, Toys"R"Us and other fine retailers.
It features a 7" TFT display and measures 0.41" x 4.8" x 7.6". Weight including battery is 0.76 lbs and it features a built-in microSD slot supports up to 32 GB of additional storage. Connectivity includes WiFi, Bluetooth 3.0, USB 2.0 host, and integrated IR for home theater control.
A choice for every consumer
In addition to this new version of the Galaxy Tab 2 7.0, Samsung continues to offer the Galaxy Tab 2 in classic black or white in both 10.1 and 7.0 sizes. As well, the award-winning Galaxy Note 10.1 with integrated S-pen is available in black or white as well.
More information can be found at www.samsung.com.
Source: Samsung
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/NFJgSBVWzdI/
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Jan. 25, 2013 ? Simon Fraser University earth scientist Diana Allen, a co-author on a new paper about climate changes' impacts on the world's ground water, says climate change may be exacerbating many countries' experience of water stress.
"Increasing food requirements to feed our current world's growing population and prolonged droughts in many regions of the world are already increasing dependence on groundwater for agriculture," says Allen. "Climate-change-related stresses on fresh surface water, such as glacier-fed rivers, will likely exacerbate that situation.
"Add to that our mismanagement and inadequate monitoring of groundwater usage and we may see significant groundwater depletion and contamination that will seriously compromise much of the world's agriculturally-grown food supply."
In Ground Water and Climate Change, Allen and several other international scientists explain how several human-driven factors, if not rectified, will combine with climate change to significantly reduce useable groundwater availability for agriculture globally.
The paper was published in late 2012 in the journal Nature Climate Change.
The authors note that inadequate groundwater supply records and mathematical models for predicting climate change and associated sea-level-rise make it impossible to forecast groundwater's long-range fate globally.
"Over-pumping of groundwater for irrigation is mining dry the world's ancient Pleistocene-age, ice-sheet-fed aquifers and, ironically, at the same time increasing sea-level rise, which we haven't factored into current estimations of the rise," says Allen. "Groundwater pumping reduces the amount of stored water deep underground and redirects it to the more active hydrologic system at the land-surface. There, it evaporates into the atmosphere, and ultimately falls as precipitation into the ocean."
Current research estimates oceans will rise by about a metre globally by the end of the century due to climate change. But that estimation doesn't factor in another half-a-centimetre-a-year rise, says this study, expected due to groundwater recycling back into the ocean globally.
Increasing climate-change-induced storm surges will also flood coastal areas, threatening the quality of groundwater supplies and compromising their usability.
This is the second study that Allen and her colleagues have produced to assist the Intergovernmental Panel on Climate Change (IPCC) in assessing the impact of climate change on the world's groundwater supply.
The IPCC, established by the United Nations Environmental Programme and the World Meteorological Organization in 1988, periodically reviews the latest research on climate change and assesses its potential environmental and socio-economic impacts.
This study is one of several guiding the IPCC's formulation of upcoming reports, the first being about the physical science behind climate change, due Sept. 2013.
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updated 10:35 p.m. ET Jan. 27, 2013
HONOLULU - A handful of shenanigans and plenty of points - yet still another ho-hum Pro Bowl.
Whether the NFL's all-star game will return next season is a something the league will ponder the next few months after the NFC's 62-35 blowout of the AFC on Sunday.
"It's been an unbelievable week," Seattle rookie quarterback Russell Wilson said, "And the thing was, if you watched us, everybody was competing today and it was really awesome."
Wilson at least got the crowd pumped up in the second half with some nifty scrambles and three passing touchdowns. There was also Houston's sack-happy defensive end J.J. Watt going out for a couple of passes as a wide receiver, and retiring Green Bay center Jeff Saturday snapping to two Mannings on opposite teams.
But while the NFC appeared unstoppable on offense, with nearly each player putting up fantasy-worthy lines in limited play, the AFC had five turnovers and scored most of its points well after the game was no longer competitive.
Minnesota tight end Kyle Rudolph was voted the game's MVP with five catches for 122 yards and a touchdown.
"Guys were competing, guys wanted to win and guys want to keep the game here," Rudolph insisted. "That was the point before the game. We want to keep this game rolling for future Pro Bowlers."
Watt, who had 20 1/2 sacks for Houston, lined up as a wide receiver on the AFC's third play from scrimmage, but missed a pass from Denver quarterback Peyton Manning. He was targeted one more time, but didn't make a catch.
He later showed a television camera a bloody left pinkie, joking with NBC broadcasters that it was proof that the players were trying.
"Hey, Commish, we're playing hard," Watt said as he showed his finger.
Roger Goodell has said the Pro Bowl won't be played again if play didn't improve this year. Last year, fans in Hawaii booed as lineman were clearly not trying. On one play in that game, Minnesota defensive end Jared Allen did a barrel roll to switch positions with a teammate.
If players were coasting this time around, it was less obvious. The AFC just played poorly. And fans didn't boo much - the stands were relatively empty even though the game sold enough tickets to lift a local television blackout.
The game was trending on Twitter in the United States early on, but quickly gave way to the Screen Actors Guild Awards and the WWE Royal Rumble.
Saturday, retiring at the end of this season, played for both teams, though he came representing the NFC. He lined up on one play for the AFC to snap the ball one last time to Manning, his longtime former Colts teammate.
Saturday said it meant a lot to him that the Broncos quarterback, whom Saturday called a true friend, orchestrated the stunt.
"He's got a little more pull than I got," Saturday said. "He got it all set up and timed up for me, so it was really nice of him to do that."
Saturday played 13 seasons in Indianapolis, all with Manning - except 2011, when Manning was out with a neck injury. Saturday then played later in the game for the NFC, snapping to Peyton's brother, Giants quarterback Eli Manning.
Saturday's last play on the field was a passing touchdown by Eli Manning.
Peyton Manning said it was nice for the NFL to allow the play to happen.
"It's something that I'll always remember," he said, "that he'll always remember to kind of get that one, final snap together after the thousands that we've taken together."
Even as the NFC piled up touchdowns, the game struggled for memorable moments after Saturday's momentary switch.
In the second quarter, referee Ed Hochuli drew cheers when announcing a pass interference penalty on Denver cornerback Champ Bailey in the second quarter - the first flag of the game.
"Yes, there are penalties in the Pro Bowl," Hochuli said, drawing laughs and loud cheers.
Giants wideout Victor Cruz broke a Pro Bowl record with 10 catches. Tampa Bay receiver Vincent Jackson had 91 yards and two touchdowns. Eli Manning threw for 191 yards and two touchdowns.
Cincinnati's A.J. Green had three TD catches for the AFC.
NFL officials said earlier in the week that the league wants to decide the future of the Pro Bowl by the time next season's schedule is released in April.
"We understood exactly what (Goodell) wanted, guys were making plays all over the field," Cruz said. "There was a little bit more high intensity than in years past and we were excited to play."
? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Source: http://nbcsports.msnbc.com/id/50610587/ns/sports-sunday_night_football/
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Published: Saturday, January 26, 2013, 9:00?p.m.
Updated 4 hours ago
? Heartland Homes, which is now part of NVR Inc., plans a preview of its 14-lot residential subdivision, Waterford Place in MCandless, from 5:30 to 7:30 p.m. Thursday at its Pinecrest community in Pine. The new community will be off Ringeisen Road. The homes will feature HardiePlank siding, brick water tables, concrete driveways and upgraded landscape packages, said Kevin Oakley of Heartland.
? At a hearing Thursday before the Pittsburgh Zoning Board of Adjustment, Jacob B. Metz will seek an exception to operate a recycling processing center in 10,400 square feet of a two-story structure at 2235 Mary St., South Side. Kenneth Jeffrey Hanna Jr. wants to use 600 square feet in an attached garage of 919 N. St. Clair St., Highland Park, for brewery manufacturing as a home occupation.
E Squared Construction wants an OK for a 4,800-square-foot expansion of a restaurant and banquet hall in a three-story structure at 710 N. Homewood Ave. Melody Farrin wants to have four poultry birds as an urban agriculture accessory at a single-family dwelling, 1126 Winterton St., Highland Park. Waterford Land Partners LP will return to seek approval for 31 two-story single-family attached dwellings on Davison Street, Lawrenceville.
? Dan Jones of Precision Home Inspections Inc., based in Connellsville, was honored by the American Society of Home Inspectors for 15 years of membership. Jones, a ASHI certified inspector since 1998, does pre-listing and maintenance inspections in southwestern Pennsylvania. Precision conducts inspections of new and previously owned homes,
? A free seminar, ?Is Real Estate Your New Career?? will be held from 7 to 8 p.m. Wednesday at Northland Public Library, 300 Cumberland Road, off McKnight Road, by Howard Hanna Real Estate Services. Cindy Criss and Cathy Winghart will co-host the event. For reservations, call 412-934-3400 or 412-366-3100.
? The franchise owners of CMIT Solutions in Western Pennsylvania, a provider of managed services and other computer consulting services, will expand the number of offices by up to five over the next few months. Two offices are already in the region. Sam Gupta and his partner, Sunny Yalamarthy, are looking at Downtown, Monroeville and the South Hills, among other sites. Karen Stephens covers northern Allegheny and southern Butler counties. There is a North Hills office.
? Allegheny County and the county Parks Foundation will host two meetings on Wednesday to obtain public input on projects in North Park and South Park. At the North Park meeting in Rose Barn, Pearce Mill Road, GAI Consultants will show schematic designs for the Lake Trail Gateways and Municipal Row Path. At the South Park meeting in the Park Home Economics Building, Buffalo Drive, Pashek Associates will present design options for the Playgrounds Oval. Both meetings start at 7 p.m.
? America?s Best Contacts & Eyeglasses has opened in Town Marketplace, Monaca, its seventh store in the region.
Sam Spatter is a staff writer for Trib Total Media.
He can be reached at 412-320-7843 or sspatter@tribweb.com.
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There are currently no comments for this story.Source: http://triblive.com/business/realestate/3335341-74/park-road-south
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After being unveiled at the close of 2012, yesterday Samsung announced the Galaxy Grand for its native South Korea. At a glance the domestic build of this handset looks nearly identical to its foreign counterpart, however the device's spec sheet tells a different story. Opposed to a meager dual-core chip and faux 4G connectivity, the Korean version of the Galaxy Grand sports a beefy 1.4GHz processor, along with LTE network support. Additional unique features include NFC capabilities and USB 3.0. Aside from these hometown enhancements, the device's 5-inch WVGA display, dual-cameras and Android 4.1 operating system remain intact. Set to be available on three unannounced Korean carriers at an undisclosed time, potential suitors can pick up this superior version of the Galaxy Grand for 350,000 won (around $325).
Filed under: Cellphones, Mobile, Samsung
Via: Android Headlines
Source: Samsung (translated)
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/QLvmKPu2Mgg/
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CARACAS, Venezuela (AP) ? Venezuelan President Hugo Chavez's condition has improved and he is now optimistic as he faces more treatment following cancer surgery, his vice president said Saturday.
Vice President Nicolas Maduro said after meeting with Chavez in Cuba that the ailing president is now "in the best moment we've seen him in these days of struggle" following his Dec. 11 cancer surgery. Chavez hasn't been seen or spoken publicly since before the operation, and his government has said he suffered complications including a severe respiratory infection but has recently been getting better.
Maduro spoke on state television early Saturday after returning from Havana to Venezuela. He said he was leaving shortly for a summit meeting in Chile and was taking a written message from Chavez.
Maduro said Chavez also sent messages for Venezuelans, including that he said he was "very optimistic in what we're doing." Maduro said that referred to the president's treatment and that Chavez is "hanging on to Christ and to life."
The vice president, whom Chavez designated as his successor before the operation, spoke on television surrounded by officials including Defense Minister Diego Molero and Information Minister Ernesto Villegas. Maduro said that Villegas would give a more detailed update on Chavez's health later Saturday.
Chavez has undergone repeated surgeries, chemotherapy and radiation treatment for an unspecified type of pelvic cancer. He has undergone much of his treatment in Cuba.
The 58-year-old president won re-election in October, and lawmakers indefinitely put off his inauguration earlier this month in a decision that was condemned by opponents but upheld by the Supreme Court.
Maduro said that Chavez sent several messages for his supporters in Venezuela, including urging them to be alert about opponents seeking to do harm. He did not elaborate.
The vice president said that Chavez had reviewed reports about various matters and had made decisions. He also said that Chavez had signed documents, and the vice president showed the signature in red ink.
He said one of the documents signed by Chavez related to the selection of his socialist party's candidates for mayoral elections later this year.
Source: http://news.yahoo.com/venezuela-vp-ailing-chavez-best-moment-072401926.html
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Evolution has revolutionized our modern scientific understanding of natural history and how our bodies came to be. Yet evolutionary insights regarding health and disease are not typically emphasized with patients.
Medical education focuses on proximate causes of disease ? infection, trauma, cellular regulation, etc. ? as opposed to evolutionary understandings of how our traits and responses came to be in the first place. What evolutionary insights are there for clinical medicine?
Medical conditions can occur when there is a mismatch between our evolved bodies and our particular society and environment. This idea challenges some of our notions of disease.
Hardly a day goes by when I don?t see patients with lactose intolerance, allergies, obesity, anxiety, near-sightedness, ADHD, and flu symptoms. The lactase gene spread rapidly in historical populations with dairy husbandry. But 70% of the world?s population is lactose intolerant, all of whom are ?normal? in the context of their environments that were, until recently, lactose-free.
Allergies and autoimmune conditions are more common in developed societies where infections occur less frequently. This suggests a mismatch between our evolved immune system and our current environment. Recent evidence suggests that the incidence of autoimmune Crohn?s disease has risen in places where the incidence of gastrointestinal worm infection has fallen.
Obesity likely represents a mismatch between our food preferences which evolved in environments of relative food scarcity, and modern environments with increased food availability and decreased activity levels.
Anxiety may have been an evolutionarily useful response ? think of the advantage of being jumpy when you hear rustling in the tall grass in an African savannah ? but now may be an inappropriate expression for our current environment.
According to a recent study, children who are genetically susceptible to near-sightedness are less likely to become nearsighted if they spend more time outdoors.? This suggests near-sightedness may in part result from a mismatch between the outdoor environment in which we evolved and modern indoor activities such as reading and playing video games.
With an evolutionary perspective, conditions such as attention deficit hyperactivity disorder may be conveyed not as a disease, but rather a mismatch between a patient?s evolved nature and our particular society?s educational expectations. In all these conditions, an evolutionary approach helps clinicians and patients see medical conditions as contextual, rather than as an inherent defect. Evolution ? natural history ? becomes relevant.
Fever, cough, vomiting, diarrhea, etc. are evolutionary host defenses to expel infections, not, as patients often believe, infections themselves. Nonetheless the suffering can be marked. If treatment is provided to alleviate these symptoms, will our body?s defense against infections be weakened? This area is ripe for additional scientific research.
Like the early days of pharmacology and microbiology, it is too soon to predict the extent of clinical relevance that an explicit evolutionary understanding can yield. Evolutionary thinking has already directly impacted clinical medicine in areas such as genetics and vaccine design. Evolutionary principles also inform public health measures, such as the campaign to avoid inappropriate antibiotic use in humans and livestock to help prevent the evolution of resistant pathogen strains.
Just because a trait evolved does not make it good or bad. Evolution itself is impersonal and morally neutral.? It is up to us to provide deliberate values into the blind shuffle of evolutionary selection. An evolutionary scientific understanding provides greater wisdom into health and illness. Even in this world of technological marvels, the ?history and physical? (H&P) is often emphasized as a physician?s most valued diagnostic strategy. In essence, evolution is history. With an evolutionary perspective, the ?H? in ?H&P? can be understood and appreciated at a deeper level.
Image: Genome.gov
Source: http://rss.sciam.com/click.phdo?i=f5dc0e410abf2bfc22e9a8507842017c
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Scientists find cancer-causing virus in the brain, potential connection to epilepsy
Friday, January 25, 2013Researchers at Shriner's Hospital Pediatric Research Center at the Temple University School of Medicine, and the University of Pennsylvania have evidence linking the human papillomavirus 16 (HPV16) ? the most common cause of cervical cancer ? to a common form of childhood epilepsy. They have shown for the first time that HPV16 may be present in the human brain, and found that when they added a viral protein to the brains of fetal mice, the mice all demonstrated the same developmental problems in the cerebral cortex associated with this type of epilepsy, called focal cortical dysplasia type IIB (FCDIIB). The findings suggest that the virus could play a role in the development of epilepsy.
The results also mean that doctors may have to re-think their approach to treating this type of epilepsy, and perhaps consider other therapeutic options related to HPV, an infectious disease.
"This is a novel mechanism, and it fills a gap in our understanding about the development of congenital brain malformations," said Peter Crino, MD, PhD, Professor of Neurology at Temple University School of Medicine, and a member of Shriner's Hospital Pediatric Research Center, and the senior author of a recent report in the Annals of Neurology.
"If our data are correct, future treatment of cortical dysplasia could include targeted therapy against HPV16 infection, with the goal of halting seizures. Identifying an infectious agent as part of the pathogenesis of brain malformations could open up an array of new therapeutic approaches against various forms of epilepsy."
FCDIIB is a developmental malformation in the cerebral cortex, the area of the brain that plays key roles in thought, perception and memory. It is a common cause of both pediatric and adult epilepsy ? especially difficult-to-treat forms of epilepsy ? and it is thought to occur in the womb during early brain development. The condition is characterized by a disorganized cellular structure and enlarged, "balloon cells." Current treatments include surgery and medication.
Balloon cells contain a signaling cascade called the mammalian target of rapamycin complex 1 (mTOR1), which is important for cellular growth, proliferation and division, particularly in brain development. Other scientists have recently found the mTOR pathway is activated by the HPV16 E6 oncoprotein.
While there had never been any studies indicating that HPV16 could infect the brain, Dr. Crino saw a potential connection. "This is a sporadic, congenital brain malformation associated with mTOR signaling with no genetic predisposition," he said. "Based on various cellular and cell signaling similarities between cervical dysplasia and focal cortical dysplasia, this led me to a hypothesis that the HPV protein could be detected in FCDIIB."
To find out, the investigators first examined FCDIIB tissue samples from 50 patients for evidence of the HPV16 E6 protein. They found that all of the samples were positive for the protein in the balloon cells, but not in regions without balloon cells or in 36 control samples from healthy individuals.
They next examined the samples' genetic material by several sophisticated molecular techniques to look for evidence of HPV16 E6, and compared the findings to tissue from healthy controls and tissue from patients with different types of brain malformations and epilepsy. Again, every sample of FCDIIB was found to contain HPV16 E6 protein, whereas the control specimens and tissue from other types of dysplasia and conditions did not.
Finally, in a series of experiments, the scientists painstakingly delivered the E6 protein into the brains of fetal mice. "If E6 is the causative element for HPV cervical dysplasia and focal cortical dysplasia, putting the protein into a fetal mouse brain should disrupt the cortical development," Dr. Crino explained. When the scientists did this, they found that the fetal mouse brains did indeed develop brain malformations.
Dr. Crino plans to investigate other forms of cortical dysplasia to see if HPV or related viral proteins can be found. He and his team aren't sure how the virus gets into the brain, but their results suggest that an HPV infection in the placenta could be one possible path. The exact mechanism by which HPV16 might cause a malformation and epilepsy remains to be determined. He acknowledged several potential implications from the findings.
"We are going to have to think about this epidemiologically as an infectious disease, not a genetic disorder. In terms of prevention, with current HPV vaccination, we have a potentially modifiable disease," he said. "In addition, if in fact this type of epilepsy represents a disorder of mTOR signaling, then one strategy could be, rather than treating the patients with anti-epileptic drugs, is to perhaps use mTOR inhibitors.
"The million dollar result would be to show it is possible to induce a brain malformation with an E6 infection, and the animal develops epilepsy," Dr. Crino said. "It would be even better if we showed that it is preventable."
###
Temple University Health System: http://www.templehealth.org/
Thanks to Temple University Health System for this article.
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Overview:
As one of the oldest congregations in Chicago, Temple Sholom is a vibrant and spiritual Reform Jewish community. We strive to educate and inspire children, youth and adults to participate actively in worship, Torah study and Jewish life experience, and to put Reform Jewish religious and ethical principles into action.? We seek to enrich the lives of our members, contribute to the continuance and vitality of the Jewish people, and work in pursuit of Tikkun Olam ? to help ?repair the world.?
Job Description:
The ideal candidate will provide leadership and direction for the Gan Shalom Early Childhood Education Center and for all early childhood programming at the Temple.? The Director will be responsible for:
The Director is also a member of the senior staff of the Temple and will be involved in all aspects of family engagement programming at the synagogue.
Qualification/Requirements
We offer a salary commensurate with experience, skills and abilities and full benefit package.
This is a 12 month position with a varied workweek, including some responsibilities on Shabbat and Jewish Holidays.
Please submit a cover letter and curriculum vitae to ECEsearch@sholomchicago.org
Job Categories: Education/Teaching, Featured, Indeed, Non-Profit, Other, and Synagogue. Job Types: Full-Time. Job expires in 179 days.
29?total views, 10?today
Source: http://www.jewishjobster.com/jobs/early-childhood-education-director/
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Contact: Gozde Zorlu
gozde.zorlu@frontiersin.org
Frontiers
Yoga has positive effects on mild depression and sleep complaints, even in the absence of drug treatments, and improves symptoms associated with schizophrenia and ADHD in patients on medication, according to a systematic review of the exercise on major clinical psychiatric disorders.
Published in the open-access journal, Frontiers in Psychiatry, on January 25th, 2013, the review of more than one hundred studies focusing on 16 high-quality controlled studies looked at the effects of yoga on depression, schizophrenia, ADHD, sleep complaints, eating disorders and cognition problems.
Yoga in popular culture
Yoga is a popular exercise and is practiced by 15.8 million adults in the United States alone, according to a survey by the Harris Interactive Service Bureau, and its holistic goal of promoting psychical and mental health is widely held in popular belief.
"However, yoga has become such a cultural phenomenon that it has become difficult for physicians and patients to differentiate legitimate claims from hype," wrote the authors in their study. "Our goal was to examine whether the evidence matched the promise."
Benefits of the exercise were found for all mental health illnesses included in the review, except for eating disorders and cognition problems as the evidence for these was conflicting or lacking.
Dr. P. Murali Doraiswamy, a professor of psychiatry and medicine at Duke University Medical Center, US, and author of the study, explained that the emerging scientific evidence in support of the 5,000 year old Indian practice on psychiatric disorders is "highly promising" and showed that yoga may not only help to improve symptoms, but also may have an ancillary role in the prevention of stress-related mental illnesses.
The review found evidence from biomarker studies showing that yoga influences key elements of the human body thought to play a role in mental health in similar ways to that of antidepressants and psychotherapy. One study found that the exercise affects neurotransmitters, inflammation, oxidative stress, lipids, growth factors and second messengers.
Unmet need among mental health patients
Depression alone affects more than 350 million people globally and is the leading cause of disability worldwide, according to the World Health Organization (WHO). On World Mental Health Day last year, the WHO called for improved access to treatments.
While there has been an increase in the number of medications available for mental health disorders, many of which can be life saving for patients, there remains "a considerable unmet need," according to Dr. Meera Balasubramaniam, lead author of the study, who is also based at Duke University, US.
Poor compliance and relapse as well as treatment resistance are growing problems, and medications are expensive and can leave patients with significant side effects.
The Primary Care study, carried out by WHO, found that 60% of patients were still depressed after a year of being treated with an anti-depressant and a National Institute of Mental Health funded research showed remission in only one-third of patients.
"The search for improved treatments, including non-drug based, to meet the holistic needs of patients is of paramount importance and we call for more research into yoga as a global priority," said Doraiswamy. "If the promise of yoga on mental health was found in a drug, it would be the best selling medication world-wide," he added.
There are many benefits associated with practicing yoga for improving mental health, including, fewer side effects, relatively low cost, generally good access and the improvement of physical fitness, added the authors.
The authors also note that while the results are promising, the findings should be viewed as preliminary because all studies of yoga to date have consisted of small samples, and more rigorous research will be needed before the exercise can be applied to help patients with mental health disorders.
###
Researcher Contact:
Dr. P. Murali Doraiswamy
Duke University Medical Center
murali.doraiswamy@duke.edu
Article Information: Yoga on our Minds: A Systematic Review of Yoga for Neuropsychiatric Disorders. Authors: Meera Balasubramaniam, Shirley Telles and P. Murali Doraiswamy.
Front. Psychiatry DOI=10.3389/fpsyt.2012.00117
For online articles, please provide full citation and a link to the study, which is available for anyone to read free of charge. The study will be published when the embargo lifts on the following URL: http://www.frontiersin.org/Affective_Disorders_and_Psychosomatic_Research/10.3389/fpsyt.2012.00117/abstract
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Gozde Zorlu
gozde.zorlu@frontiersin.org
Frontiers
Yoga has positive effects on mild depression and sleep complaints, even in the absence of drug treatments, and improves symptoms associated with schizophrenia and ADHD in patients on medication, according to a systematic review of the exercise on major clinical psychiatric disorders.
Published in the open-access journal, Frontiers in Psychiatry, on January 25th, 2013, the review of more than one hundred studies focusing on 16 high-quality controlled studies looked at the effects of yoga on depression, schizophrenia, ADHD, sleep complaints, eating disorders and cognition problems.
Yoga in popular culture
Yoga is a popular exercise and is practiced by 15.8 million adults in the United States alone, according to a survey by the Harris Interactive Service Bureau, and its holistic goal of promoting psychical and mental health is widely held in popular belief.
"However, yoga has become such a cultural phenomenon that it has become difficult for physicians and patients to differentiate legitimate claims from hype," wrote the authors in their study. "Our goal was to examine whether the evidence matched the promise."
Benefits of the exercise were found for all mental health illnesses included in the review, except for eating disorders and cognition problems as the evidence for these was conflicting or lacking.
Dr. P. Murali Doraiswamy, a professor of psychiatry and medicine at Duke University Medical Center, US, and author of the study, explained that the emerging scientific evidence in support of the 5,000 year old Indian practice on psychiatric disorders is "highly promising" and showed that yoga may not only help to improve symptoms, but also may have an ancillary role in the prevention of stress-related mental illnesses.
The review found evidence from biomarker studies showing that yoga influences key elements of the human body thought to play a role in mental health in similar ways to that of antidepressants and psychotherapy. One study found that the exercise affects neurotransmitters, inflammation, oxidative stress, lipids, growth factors and second messengers.
Unmet need among mental health patients
Depression alone affects more than 350 million people globally and is the leading cause of disability worldwide, according to the World Health Organization (WHO). On World Mental Health Day last year, the WHO called for improved access to treatments.
While there has been an increase in the number of medications available for mental health disorders, many of which can be life saving for patients, there remains "a considerable unmet need," according to Dr. Meera Balasubramaniam, lead author of the study, who is also based at Duke University, US.
Poor compliance and relapse as well as treatment resistance are growing problems, and medications are expensive and can leave patients with significant side effects.
The Primary Care study, carried out by WHO, found that 60% of patients were still depressed after a year of being treated with an anti-depressant and a National Institute of Mental Health funded research showed remission in only one-third of patients.
"The search for improved treatments, including non-drug based, to meet the holistic needs of patients is of paramount importance and we call for more research into yoga as a global priority," said Doraiswamy. "If the promise of yoga on mental health was found in a drug, it would be the best selling medication world-wide," he added.
There are many benefits associated with practicing yoga for improving mental health, including, fewer side effects, relatively low cost, generally good access and the improvement of physical fitness, added the authors.
The authors also note that while the results are promising, the findings should be viewed as preliminary because all studies of yoga to date have consisted of small samples, and more rigorous research will be needed before the exercise can be applied to help patients with mental health disorders.
###
Researcher Contact:
Dr. P. Murali Doraiswamy
Duke University Medical Center
murali.doraiswamy@duke.edu
Article Information: Yoga on our Minds: A Systematic Review of Yoga for Neuropsychiatric Disorders. Authors: Meera Balasubramaniam, Shirley Telles and P. Murali Doraiswamy.
Front. Psychiatry DOI=10.3389/fpsyt.2012.00117
For online articles, please provide full citation and a link to the study, which is available for anyone to read free of charge. The study will be published when the embargo lifts on the following URL: http://www.frontiersin.org/Affective_Disorders_and_Psychosomatic_Research/10.3389/fpsyt.2012.00117/abstract
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-01/f-fps012213.php
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Federal authorities in Colorado have arrested a 35-year-old man with a "Fire Obama" poster in his window who allegedly worried the Obama administration was going to take away his guns on charges he tried to trade bombs for cocaine.
Richard Sandberg came to the attention of federal authorities after an informant indicated he tried to trade weapons for cocaine, according to an affidavit by ATF task force officer James Anderson. The ATF introduced a separate undercover informant into their investigation who tired to set up a deal with Sandberg. Sandberg allegedly told the informant he was a former Marine who served in Iraq, Somalia, Africa, and Pakistan and the government "paid him hundreds of thousands of dollars to learn how to build bombs and kill people," according to Anderson's affidavit.
Sandberg claimed a right wing declaration of independence/constitutionalist political manifesto and made disparaging remarks about the current administration and them wanting to take away his guns. Sandberg made numerous threatening statements towards law enforcement (LE) and specifically ATF, stating if any LE or ATF came inside his house, to take his guns, it would be a bad day for them and lots of them would die. Sandberg stated that he was ready and willing to die. Sandberg told SA Abraham that no ATF, or LE SWAT team was capable of taking him out of his house, that it would take a US Marine SF Recon team to take him out, because they were the only ones capable.
A local news station said there was a "Fire Obama" sign posted in a second floor window of Sandberg's home. Anderson's whole affidavit is worth a read. It's embedded below.
Sanberg
?
Follow Ryan J. Reilly on Twitter: www.twitter.com/ryanjreillly
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The controversy over whether work on airborne H5N1 bird flu can be published shows that transparency is vital to upholding public trust
So the research moratorium on H5N1 bird flu is over. In 2011 I was one of the first journalists to report the discovery that H5N1 bird flu, which is highly lethal in humans, can mutate to become readily transmissible not just in birds but also in mammals like us ? while, apparently, remaining lethal.
What happened next shocked the researchers. Publication of the work was blocked, as US biosecurity experts insisted it would be crazy to tell would-be bioterrorists about this. The 39 labs around the world that do this research responded by declaring a moratorium on further work: there's little point doing research you can't publish.
A year later, the US will shortly launch a new review process to address this. This week, the labs said they would soon resume work on whether, and how, a virus now evolving across Eurasia might become an apocalyptic threat to humanity.
This resumption is good news ? but there's a proviso. Hypothetical bioterrorists aside, the real worry for many critics is the danger posed by research itself. We don't want labs to inadvertently release the virus we fear.
That doesn't just require stringent containment and more bureaucracy ? it means doing experiments only when benefits really outweigh risks. If, as seems likely, all parties involved cannot agree on that, then the whole process should at least be as transparent as possible. Top research officials in the US have been saying this, and that too is good.
But are researchers as committed to transparency? The H5N1 kerfuffle has been notable for an alarming amount of spin. Details of the findings have been reinterpreted as pressures have mounted. The experience may have left some researchers even less likely to tell us what they're doing.
The story emerged at a flu meeting in Malta in September 2011. Ron Fouchier of the Erasmus Medical Center in Rotterdam reported that he had made H5N1 able to spread between ferrets via airborne droplets, by simply passing it repeatedly between the animals.
This was the $64,000 question in flu research. At present, H5N1 cannot become a human pandemic as it does not spread this way in mammals. But can it evolve this ability? Some virologists said no. Others said it might, but the mutant would not be as lethal.
No such luck. "All the ferrets died," Fouchier told me. "We have to do more to control H5N1." He was clearly upset at the prospect of such a virus evolving naturally; so were other flu researchers at the meeting. I reported it
Fouchier had left out a lot of detail as the research had been submitted to the journal Science, which doesn't allow authors to say much before publication. When he said the ferrets all died, I thought he was referring to the ones that inhaled the virus. In fact those ferrets lived; the ones that died had had that same virus put into their windpipe.
We would have corrected the article had the researchers complained. Maybe it seemed a minor point: the team had also reported that putting a flu virus in a ferret's windpipe was the best test of its danger to humans. The transmissible virus killed in a way that might be relevant to people ? that's what mattered. The detail wouldn't have changed our conclusion.
But then the dispute over whether the work could be published blew up, and The New York Times charged that this research was just too dangerous.
In February last year, the researchers' story had changed dramatically. The press had blown things out of proportion. The mutant virus wasn't dangerous. None of the ferrets that inhaled it died, you had to practically shove it into their lungs to kill them. Anyway, animal work doesn't show what will happen in people.
Efforts to portray the transmissible virus as harmless were almost comical. One researcher told me the mutant H5N1 was no biggie ? even the 2009 pandemic flu kills in ferrets' tracheas. Ah, but only one in three ? the H5N1 killed them all, so not quite the same.
When the research was finally published, none of the spin seemed very relevant. The message of Malta remained: H5N1 became airborne in mammals, and could still kill. That's enough. Yes, this is animal work: if a virus that kills in a ferret's throat, but not in its nose, emerges in nature, we may get lucky. Or maybe we'd best not inhale.
Some defensiveness is understandable if scientists fear work they rightly consider vitally important may be banned. Yet full transparency is the answer. I fear that lesson has not sunk in. After the papers were published, one of the researchers insisted to me that there was no reason why he should ever talk to a journalist; this week that person begged journalists to tell the public the researchers' side of the story, so they wouldn't get this kind of opposition.
That's not how it's done. Transparency is an important safeguard against some who may take excessive risks (it happens) as well as showing the good that scientists do. It must serve both these functions, or no one will believe the good news.
I gave a talk in Malta too, about public communication. I told a roomful of flu researchers the old risk-management saying: strive to be, not trusted, but accountable. I got a lot of blank, angry stares.
This problem won't go away until that gets rueful, knowing nods. It isn't happening yet.
Debora MacKenzie is a consultant for New Scientist based in Brussels
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