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Friday, November 30, 2012
Can Mexico's President-elect Pe?a Nieto and Obama set a new tone? - Wilson Center in the News
?Pe?a Nieto is signaling that ? he is not going to stop confronting organized crime, but that he wants to add the economic relationship with the world and the US in particular to the priority list,? says Eric Olson, the associate director of the Mexico Institute at the Woodrow Wilson International Center For Scholars.
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Thursday, November 29, 2012
Chrome for Android updated
Chrome for Android has been updated to fix some stability issues, says Google.
This news comes on the back of Google’s announcement last week on their Google+ page that it will bring mobile Chrome version numbers up to speed with desktop versions by early next year. With desktop Chrome at version 23 right now and mobile Chrome at 18, we can expect releases to be streamlined eventually.
For reference, the stable channel for the latest Android Chrome release for ARM devices is 18.0.1025469 and 18.0.1026322 for x86 devices.
Thanks to everyone who sent this in!
 |  |
Source: http://feedproxy.google.com/~r/androidcentral/~3/IORKfW9vMWc/story01.htm
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US EPA suspends oil giant BP from new federal contracts over conduct tied to oil spill
NEW YORK (Reuters) - The ageing New York Yankees, struggling to inject youth into their roster, appear poised to sign two of their evergreen core members for one more go-round in a drive for a sixth World Series ring since 1996. Left-handed starting pitcher Andy Pettitte, 40, and all-time Major League Baseball saves leader Mariano Rivera, who turns 43 on Thursday, are reportedly on the verge of signing deals for one last campaign. Those pitchers could well be effective in 2013. Pettitte returned from a one-year retirement last season to go 5-4 with an impressive 2. ...
Source: http://news.yahoo.com/us-epa-suspends-oil-giant-bp-federal-contracts-135953310--finance.html
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Cheap Storage, Garage | Home Improvement Genuis - idedysoba's ...
Cheap Storage Ideas
For most people, a garage happens to be a really cluttered dumping ground where you may choose to put practically anything and everything which you no longer want in your house. In general, it becomes really difficult to find things as and when you require them. Your garage will also become really messy. Using some really cheap ideas, you will be able to make your garage look quite tidy. You may even be able to make room for a car.
Conduct a Garage Sale
Holding a garage sale happens to be one of the best ways to increase storage space. Get rid of all unwanted items for a weekend sale in your front yard. Get the neighbors involved in order to turn it into a really big event. It will make it really easy for you to organize the rest of the items. Some extra money can be made in the process.
Create Item Zones
You need to group like items into item zones. For instance, one area of the garage may be used solely for sporting goods. Another area may be used for automotive supplies and a third area may be used for gardening tools. You must keep the gardening items near a side door or the garage opening which allows easy access during really warm months.
Install Shelves
You are well advised to purchase inexpensive shelves for the garage walls or you need to make your own. You have to place smaller items in cardboard boxes and keep it on the shelves. Get them labeled so as to identify the contents. The lesser items you have on the floor, the more room you will have for bigger things
Make Use of the Ceiling
Cheap Storage Ideas
You need to use garage?s ceiling in an attempt to create additional floor space. You may use inexpensive hooks in order to hang items like bicycles, ropes, step ladders and cords safely during the winter months
Mobilize the Trash
If trash cans are kept in the garage, use those which have wheels it will be easier for you to create more storage space. If you store cans along the garage wall, you need to place additional shelving above the cans to use that space.
This discussion on cheap storage spaces ends here.
Source: http://homeimprovementgenuis.com/familiarize-yourself-with-ideas-for-cheap-storage/?utm_source=rss&utm_medium=rss&utm_campaign=familiarize-yourself-with-ideas-for-cheap-storage
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Source: http://idedysoba.posterous.com/cheap-storage-garage-home-improvement-genuis
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Wednesday, November 28, 2012
S.Africa's Adcock profit falls on loss of drugs
JOHANNESBURG (Reuters) - South African drugmaker Adcock Ingram reported a worse-than-expected 9 percent fall in annual earnings, hit by the loss of high-margin drugs.
The country's second-largest drugmaker has struggled in recent months after losing three drugs that contributed as much as 200 million rand in sales due to safety reasons. Its failure to win a bigger share in the government HIV/AIDS drugs supply contract added to the headwinds.
Adcock said diluted headline earnings per share - the main profit gauge in South Africa - totalled 422 cents in the year to end-September, from 465 cents a year earlier.
The results fell short of the 430 cents forecast by StarMine's SmartEstimate, which gives more weight to forecasts from top rated analysts.
"Disappointing set of results that reflect a weak pricing power," Jean Pierre Verster, an analyst at 360ne Asset Management. "It also continues to show the impact of the loss of key drugs and lower anti-retroviral drugs volumes."
South African health authorities granted drug manufacturers a 2.14 percent drug price increase for certain prescription drugs in March this year, a hike analysts say did not keep up with the rising cost of imported raw materials due to a weaker rand.
Shares in the company dropped 2.9 percent to 53.15 rand by 1357 GMT, on course for the biggest daily percentage decline in more than five months and underperforming a slightly higher JSE All-share index.
The company said sales were largely flat at 4.6 billion rand, but it raised its final dividend by 8 percent to 115 cents per share.
Shares in Adcock are down nearly 12 percent so far this year, far behind its closest rival Aspen Pharmacare, which has surged more than 60 percent.
The Midrand-based company, which aims to earn more than 30 percent of its sales outside South Africa in three years, has been dwarfed by Aspen, which has made an aggressive push in overseas markets such as Australia.
Adcock recently agreed to pay $86 million to buy a portfolio of drugs and a distribution network from India's Cosme Farma to bulk up its presence in that country's $16 billion pharmaceutical market.
Adcock's small operations in Ghana and Kenya reported no growth in sales over the period, hit by safety recalls due to illegal distribution of fake products and factory upgrades.
Source: http://news.yahoo.com/africas-adcock-fy-profit-down-lags-consensus-061732732--finance.html
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Syrian planes bomb olive press, many killed
BEIRUT (AP) ? Syrian warplanes bombed an olive press factory in the country's north on Tuesday, killing and wounding dozens of people, including farmers who were waiting to convert their olives to oil, activists said.
Two activist groups ? the Britain-based Syrian Observatory for Human Rights and the Local Coordination Committees ? say the factory is west of the city of Idlib. The LCC says at least 20 people were killed and many others wounded in the raid, while the Observatory said "tens were killed or wounded."
Both groups depend on a network of activists on the ground around the country.
President Bashar Assad's regime has been launching intense air raids on rebels in recent months, mostly in Idlib, the nearby province of Aleppo, Deir el-Zour to the east and suburbs of the capital Damascus.
The most recent air raids have killed hundreds of people, including eight children on Sunday in the village of Deir al-Asafir near the capital Damascus.
Olive oil is a main staple in Syria. Tens of thousands of tons are produced annually.
Fadi al-Yassin, an activist based in Idlib, told The Associated Press by telephone that dozens of people had gathered to have their olives pressed when the warplanes struck, causing a large number of casualties.
It was not immediately clear why the olive press was targeted. "It was a massacre carried out by the regime." said al-Yassin.
"Now is the season to press oil," said al-Yassin, noting that since many olive press factories are not functioning in the area because of the fighting in the region. A large number of people were at the one near the city of Idlib.
"Functioning olive press factories are packed with people these days," he said.
The Observatory also reported heavy fighting on the southern edge of the strategic rebel-held town of Maaret al-Numan, captured from government troops last month.
The town is on the highway that links the capital, Damascus, with the northern city of Aleppo, Syria's largest, a commercial center that has been the scene of clashes between rebels and troops since July.
The Observatory and al-Yassin said air raids on Maaret al-Numan killed at least five rebels.
Syria's conflict started in March 2011 as an uprising against Assad's regime, but quickly morphed into a civil war that has since killed more than 40,000 people, according to activists.
Source: http://news.yahoo.com/syrian-planes-bomb-olive-press-many-killed-105922244.html
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Poll: What Did You Watch Over Thanksgiving?
A record-breaking box office weekend has left little doubt that many of you spent this Thanksgiving in the movie theaters. With three returning releases dominating the returns, we saw films with real staying power take control of the weekend over new releases like "Rise of the Guardians" and "Red Dawn." But we want to know [...]
Source: http://moviesblog.mtv.com/2012/11/26/thanksgiving-poll/
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Tuesday, November 27, 2012
Telescopic View on How Things Work In Trademark India
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| Everyone loves to start their own business. In fact, an individual feels prestigious over launching their own organization or company. But least many do know the process involved in the legal aspect of setting up a company among which registering the company trademark becomes the most essential aspect. |
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While someone sets out to register the company, there are certain touchstones to be considered. The first thing is that the trademark should be unique and shouldn?t be similar to any other trademark. While going for the registration, it is necessary for the owner or proprietor to see that the trademark possesses all the features that boasts of disparateness under section 9, which is about the Trade and Merchandize Mark Act, 1958. ?This incisively makes the individuals aware of certain knowledge to keep a check whether there are any other similar trademarks that are registered. It is also best advisable to avoid the modifications over already registered trademark, which again may lead to some problems if the owner of the respective product or service trademark raises the issues legally. The customers can feel safe with the trademark registration in delhi, trademark registration in Chennai, trademark registration in Mumbai, and trademark registration in Ahmedabad,?trademark registration in pune?as they ardently work for the protection and safeguard against the unauthorized trademark utilization. When a person sets out to register the trademark, these officials any trademark registration organization will keep them updated on the availability on the trademarks and in fact inform whether there is any such similar trademark. They also give proper advice on having three different brand names so that the process of registration doesn?t get delayed. While filling the trademark registration forms at trademark registration in Delhi, trademark registration in Chennai, trademark registration in mumbai, trademark registration in Pune, etc. there is a separate column where the applicants are supposed to fill in three different trademark names, which is done incisively to avoid certain problems. In case, the first mentioned trademark name carries the similarities with other trademark registrant, then the other choices can be considered so as to complete the procedures soon. Soon after making the trademark registrations at trademark registration in Delhi, trademark registration in Chennai, trademark registration in Mumbai, trademark registration in Pune and?trademark registration in ahmedabad, etc, the individuals will be given a specific period of time, when the procedures would be completed and their trademark will be granted officially. Usually, the trademark registration in Delhi, trademark registration in chennai, trademark registration in Mumbai, trademark registration in Pune and trademark registration in Ahmedabad takes around 45-60 days. The individuals will be given something like a code or register number that can be used to see the status of the registration process over online. As a matter of fact, the online portals of trademark registration in Ahmedabad, Delhi, Chennai, Mumbai, Ahmadabad, Pune and other cities have made things easier for the individuals, who make their registration trademarks as they can keep on checking the status of trademark approval procedures constantly.? Related Tags:
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Make an easy trademark registration in delhi, which guided by Amit Sing also for trademark registration in mumbai, you can get information in trademark registration in chennai & more. |
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Source: http://www.articleshub.org/article/218857/Telescopic-View-on-How-Things-Work-In-Trademark-India.html
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Voices Against Brain Cancer Releases Statement Commending ...
Following reports of a community lending support for a young girl battling glioblastoma, Voices Against Brain Cancer releases statement.
New York City, NY (PRWEB) November 26, 2012
On November 26, 2012, nonprofit organization Voices Against Brain Cancer (VABC) releases a statement following reports of a community lending support for a young girl battling glioblastoma.
According to Amy Demelia, ?Zoe, the daughter of Jen and Pat McMorran, is battling glioblastoma, a form of brain cancer that is very rare in children. She is currently undergoing treatment at the Floating Hospital for Children at Tufts Medical Center.? Demelia goes on to state, ?Although Zoe is experiencing some difficulties on her left side as a result of a stroke, she recently was thrilled to return to cheerleading, an activity she loves. She also started the sixth grade this fall at North Attleboro Middle School, alongside her twin sister and top supporter, Avery.? The article explains, ?[D]emonstrations of support have been easy to find throughout the community.?
?The McMorran family said they want to let the community know how grateful they are for every helpful gesture and kind word they have received,? stated Demelia.
VABC representative Clay Darrohn, states, ?The hardships that the McMorran family face as their young daughter battles the devastating diagnosis of brain cancer are difficult to imagine, but it is heartwarming and inspiring to see a community lend its support and care while the family goes through this trying time. We believe that community support is essential in dealing with this disease and that through research, support and continued raising of awareness ? we can continue to find better treatment options.?
VABC has a wide variety of initiatives in place for brain cancer research, awareness and support. The organization?s research grants fund cutting-edge research programs that will have a monumental impact on the diagnosis and treatment of brain cancer. VABC currently funds research at several esteemed institutions such as Brookhaven National Laboratory, Cleveland Clinic, Columbia, Cornell, Duke, Harvard, John Hopkins, Memorial Sloan-Kettering and Yale, to name a few.
VABC?s mission is to find a cure for brain cancer by advancing scientific research, increasing awareness within the medical community and supporting patients, their families and caregivers afflicted with this devastating disease.
For press inquiries, please contact: [5W Public Relations.
#####
Alicia McAllister
5W Public Relations
646-430-5155
Email Information
Article source: http://news.yahoo.com/voices-against-brain-cancer-releases-statement-commending-north-110028138.html
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Monday, November 26, 2012
Apple's Refurbished eBay Store - Business Insider
Summary
Apple Inc. is an American multinational corporation that designs and markets consumer electronics, computer software, and personal computers. The company's best-known hardware products include the Macintosh line of computers... More ?Source: http://www.businessinsider.com/apples-refurbished-ebay-store-2012-11
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Good Habits for iPhone Encourages You to Keep Doing the Things You've Always Wanted to Do
We've discussed how helpful Seinfeld's productivity secret (aka "Don't break the chain") can be, but to give it a try you'll need a good calendar or tool to tack your habit chain. Good Habits is a free utility that fits the bill nicely, and includes some additional features that offer visual cues to keep you motivated so you don't break the chain. Overdue items are marked in red, and if you're sick, traveling, or can't hit your to-do for some reason, you can always pause it so you can return to it without having to start a new chain. The app is open source, and available now in the iTunes App Store.
Good Habits (Free) | iTunes App Store
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Sunday, November 25, 2012
David Cantone: Emprendedor Online, Internet Marketing & Business
| This entry was posted in art movies and tagged Blogger, BloggerCast, Blogging, Business, Cantone, David, Emprendedor, Internet, Marketing, Negocios, Online, Podcast, Productividad, Strategist. Bookmark the permalink. Follow any comments here with the RSS feed for this post. or leave a trackback.
Source: http://www.allmovies-online.com/david-cantone-emprendedor-online-internet-marketing-business-strategist-blogger-bloggercast-podcast-negocios-online-blogging-internet-marketing-productividad/
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Source: http://ontological-waste.blogspot.com/2012/11/david-cantone-emprendedor-online.html
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Source: http://pageterence.typepad.com/blog/2012/11/david-cantone-emprendedor-online-internet-marketing-business.html
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Source: http://hurley847.typepad.com/blog/2012/11/david-cantone-emprendedor-online-internet-marketing-business.html
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What foods can remove dark circles - Health and Fitness Tips
Black eye is often stays up late, emotional instability, eye fatigue, aging, venous blood flow velocity is too slow, the oxygen deficiency of red blood cells of the skin, eye, vein carbon dioxide and metabolic waste accumulation of excessive formation of chronic hypoxia The blood is dark and forms a stagnation caused by eye pigmentation.
Methods / steps
1, Eggs
Eggs rich in high quality protein, but the protein can promote cell regeneration, so regular consumption of eggs to increase protein intake have a certain effect to ease the formation of dark circles. Daily but the human body can only absorb a maximum of the nutrition contained two eggs, the consumption of eggs should not be more than two. Some people are used to eating raw eggs, fact, extremely digestible raw eggs also contain bacteria, and therefore suggest that you as the best food boiled eggs. In addition, lean meat, poultry, eggs, aquatic products are also rich in high quality protein, regular consumption of such foods can also help to reduce the formation of dark circles, but due to the eggs protein composition and the closest to the human body, so the best absorption effect.
2, Sesame
Sesame UFA well known, but its efficacy may eliminate dark circles fresh people aware. Sesame is rich in vitamin E, which can ease the formation of dark circles with nourishing the eye and ocular. Both make beautiful black hair, but also to eliminate dark circles, kill two birds with one stone, no wonder some people regarded as the sesame magic ?magic food?. In addition to sesame seeds, rich in vitamin E foods are peanuts, walnuts, sunflower seeds, etc.
3, Carrot
In addition to vitamin E to nourish the eye and ocular vitamin A also has this effect. Carrot choice is to increase the intake of vitamin A, can maintain the normal function of the epithelial tissue, improve dark circles. In addition, carrots contain vitamin A also helps to improve vision, especially in the dark vision. Other foods contain vitamin A, as well as animal liver, butter, eggs, alfalfa, apricots.
4, Kelp
As the iron core ingredients of a hemoglobin. Therefore, the added amount of iron can promote an increase in hemoglobin, thereby enhancing its ability to transport Oxygen and nutrients seaweed is rich in iron, so often take kelp can also ease the distress of the black eye. Containing iron-rich foods as well as animal liver, lean meat.
5, Green tea
Often use computers to drink green tea, add a specific plant nutrients, eliminate dark circles caused due to computer radiation. Green tea contains concentrated polyphenols, can inhibit free radical damage, skin support fibers and today is widely recognized as the most effective anti-free radical factor. Drink plenty of decaffeinated green tea can not only eliminate dark circles, which contains catechins, both to help the body fat metabolism, and sleep, sleep quality not only stability, but also people are less likely to have a feeling of fatigue.
This entry was posted on Saturday, November 24th, 2012 and is filed under Beauty, Health Tips. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
Source: http://www.hhtip.com/what-foods-can-remove-dark-circles-remove-the-black-eye/
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On patrol with a shark ranger in Indonesia
Conservation International works with Indonesian children to help them learn how to protect the most diverse underwater region in the world. ?NBC News' Richard Engel reports.
By Ed Flanagan, NBC News
RAJA AMPAT, Indonesia ? The remote Indonesian archipelago of Raja Ampat is home to an underwater treasure trove of coral reefs and tremendous biodiversity, miles away from polluted urban centers and human encroachment.
The faraway islands in Western Papua, regarded by many marine experts as having the potential to help restore the world's ailing coral reefs, are vulnerable to the unchecked exploitation of a lucrative treasure that is rapidly disappearing from Indonesia's waters: sharks.
China's growing appetite for the de rigueur shark fin soup has attracted fishermen from elsewhere in Indonesia and Southeast Asia to the waters around Raja Ampat's 1,500 islands.
Alarmed, conservationists and local villagers worked together to create the Misool Eco Resort and Conservation Center in 2005, establishing a 165-square-mile "No-Take Zone" that banned fishing.
Related content:
PhotoBlog: Raja Ampat archipelago: The world's last paradise
Understanding the beauty and diversity of Raja Ampat, aka 'Underwater Eden'?
Scientists rush to save manta rays, the 'pandas of the ocean'
When a neighboring village requested to take part, the area was expanded to 472 square miles, roughly the size of the city of Los Angeles.
The Misool team also recruited a group of rangers to help patrol the waters for illegal fishermen. Earlier this year, NBC News had an opportunity to go on patrol with Abdul Razak Tamher, 31, one of the first rangers.
Q: Before 2005, what were shark and fish stocks like in this area of Raja Ampat?
A: Before 2005, one of the main occupations of the people of my village was fishing. That's what we did every day and one of the big things fished were sharks. By the 2000s there were very few sharks left in the area, but in the 1980s and 90s when I was fishing there were lots of sharks. A lot of people used dynamite and potassium cyanide for fishing.
Q: So did villagers in Misool know they had to change the way things were done?
A: At that time, people here really didn't think much about shark or marine conservation. We didn't know shark fishing was illegal (prior to the formation of the No-Take Zone in 2005, the local governor had actually signed a law against shark fishing) because nobody from the government came out here to tell or educate us that it was illegal and bad for the ecology to fish sharks.
It was really through the efforts of the resort to educate the village about the importance of sharks and protecting the marine environment that we saw the importance of it and began to appreciate the natural beauty ourselves. Now if people from my village hear of a shark fishing boat coming into this area, they get really upset.
NBC News' Richard Engel talks to a Conservation International scientist as he identifies a new species of fish.
Q: Is conservation a completely foreign idea here? Isn't there a long tradition of seasonal fishing and spiritual beliefs around protecting certain animals?
A:?We've embraced principles of conservation since the beginning of our culture. They were simple ideas, but they still worked for us. For example, we would harvest clams from the ocean for six months, then depending on the ocean conditions, we would close that area for sometimes up to a year before harvesting again.
Many of the original families in this area are forbidden to eat different sea creatures like sharks or turtles or other kinds of fish. In each case, there is a reason why each family respects and protects a certain animal. It could be that a family member or fisherman generations ago was rescued by that species or guided to land at a time of need. Many still believe that if someone in the family breaks this taboo, they will get sick or something bad will happen.
Q:?In 2006, the rangers were formed with just five of you and a few of you were actually former shark fishermen. What made you make such a dramatic change in your life?
?A:?I personally wasn't involved in shark fishing, but other original rangers that were here in the beginning and their village elders were shark fishermen. Even though they were shark fishermen and lived off the harvest of the ocean, they realized that they needed to preserve this area and the marine life for future generations to come.
Many of us felt ? and still feel today ? that if we told our children or grandchildren that there were lots of fish and sharks in the sea around these islands and they went there and saw none they would think that we were liars and we just couldn't allow that to happen.
Q:?What was it like in the early days with the rangers?
A:?The rangers weren't really effective until 2009 because at that time there was only one speed boat that was always busy getting lumber for the construction of the resort. So we would only go out if we saw an illegal boat go past the resort. From 2006-2009, we went out almost every day. In the months of June and July, the area was choked with shark finning boats from as far away as Java that cast long lines with sometimes 1,000 or 2,000 hooks to catch sharks.
To expel the foreign boats, it wasn't a problem. We would just go up to the boats and tell them leave and they would go. Local fishermen were tougher. Most of the problems had to do with local fishermen not agreeing with the contract we signed with Misool Eco Reserve to create the no-take zones or claiming they were not around when the contract had been reached. They would also say we have it easy since we work as rangers and make a lot of money, so we don't need to fish like they did.
Q:?How soon after the reserve formed did you start to see results from the sanctuary?
A:?After two or three years, I started to see a lot of sharks in the lagoons and my friends who went diving began to see more fish. There were just some researchers here in Misool who were shocked by the amount of fish who were in the protected areas. The results have just been amazing.
Q:?How have the villages in the area adapted to the sanctuary?
A:?In the beginning, there were a lot of problems with the villagers not understanding the rangers' mission. The most important thing we did to get people behind us was to use Adat, or traditional Papuan village law. This was done by developing a close relationship with the ancestral village head, as he holds the power of the village and so people will listen to what he says. If we didn't have the village head, then it would have been difficult to enforce the rules of the sanctuary.
Q:?What's next for the rangers in the coming years?
A:?We all hope the ranger patrol can continue forever and that we have the resources to keep recruiting young people from the villages to the patrol. We now have three ranger stations built and we hope to have three rangers in every station with small, fuel-efficient boats that can be used to spot illegal fishermen and intercept them until support can show up.
The other big problem we'd like to fix is communication. Radio communication in this region of Raja Ampat is difficult because all the radios we have now are line-of-sight and the islands interfere with signal within short distances. The plan is to build a main radio/repeater station that will cover the entire area so that there is clear contact throughout the sanctuary.
To donate to the Misool ranger patrols, click here.
More world stories from NBC News:
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Saturday, November 24, 2012
Birth Control Pills Sold OTC? Smart Move, Doctors Say - Health ...
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Birth control pills should be sold over-the-counter (OTC), according to the nation?s leading group of obstetricians and gynecologists.
The American Congress of Obstetricians and Gynecologists (ACOG) said in a statement this week that the move would reduce an unacceptably high rate of unintended pregnancies that costs taxpayers about $11.1 billion each year. About half of all pregnancies in the U.S. are unintended.
Health.com: 16 Worst Birth Control Mistakes
Other countries sell birth control pills without a prescription, including Jamaica, Mexico, Kuwait and Thailand.
Birth control pills do have some risks, including a small chance of a blood clot, but these risks don?t outweigh the benefits, says ACOG.
?Nothing in life is without risk,? says Jill Rabin, MD, chief of ambulatory care, obstetrics and gynecology and head of urogynecology at Long Island Jewish Medical Center in New Hyde Park, NY, who supports the move.
?In pregnancy, women produce more estrogen and progesterone than when they take a birth control pill,? she says. ?If you have a reproductive-age woman who doesn?t want to be pregnant either by choice or for a medical reason, it?s safer to take the pill rather than get pregnant.?
Health.com: 12 Types of Birth Control
Some questions remain unanswered though, including a big one about cost.
Thanks to President Obama?s Affordable Care Act, contraception?including birth control pills?is free for women who have employer-sponsored insurance (although woman may have a co-pay for some branded drugs, and those without insurance are out of luck).
Would making birth control pills available over-the-counter shift the bill back to women? Most insurance companies don?t cover non-prescription drugs, so it?s unclear who would pay if the pill was sold at the local pharmacy without a prescription.
And then there?s the question of whether a shift from prescription to over-the-counter status of birth-control pills would ever actually happen. Dr. Rabin, for one, believes it has ?a good chance of happening,? given the experience in other parts of the world.
Health.com: Birth Control For Women Over 30
While there are concerns that women who shouldn?t be taking the pill for health reasons might do so anyway if the drugs were available over-the-counter, research suggests this is unlikely, according to ACOG. Another concern?that women will skip important health checkups if they don?t have to see their doc for a prescription?also doesn?t hold up, they said.
Surveys have shown that women are able to ?self-screen? to determine if they are at higher-than-average risk for side effects. Pharmacists, too, were able to screen out inappropriate candidates using check lists.
In other countries where the pill is already available over-the-counter, studies show women still get their annual gynecological check-ups.
?Oral contraceptives have been out for many, many, many years in this country,? said Gerald F. Joseph, MD, ACOG?s vice president, practice activities, in a statement. ?And although no drug is perfectly safe, even aspirin has its side effects, that oral contraceptives are a relatively safe drug, the benefits far outweigh the risks.?
Source: http://news.health.com/2012/11/23/birth-control-pills-sold-otc-smart-move-doctors-say/
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Reasons to Hire a Professional Wedding Photographer
Home | Arts & entertainment | Photography 
Though wedding is a beautiful and long-awaited event, it is also very busy and stressful. Indeed, there are lots of things to keep in mind and arrange in order to have unforgettable celebration. If you miss even the smallest thing, the whole celebration may be messed up.
One of the main things of wedding planning is the choice of photographer. If you forget to hire a professional photographer, all other preparations will become vain, because you will have no memories. You will have no pictures to show to your friends or relatives that were not present at your wedding. Besides your children will not be able to see how young and beautiful you were. Having wedding pictures is very important, because these are the best memories of your happy day. They will remind you of your special day long after the wedding dress is pushed to the back of your closet.
Though lots of people still ask their relatives or friend to take photos and capture the most remarkable moments of the wedding ceremony, it is always better hiring a professional photographer. The difference between the photos made by photographer and amateurs is huge. Only a professional can make amazing and unique photos that will not let you forget about that special day. Though the services offered by a professional photographer will cost you additional money, these expenditures will allow you to have the best memories that you can share with your friends, children and even grandchildren.
The right choice of a photographer is very important. There are many wedding photographers that claim to be professional, but when you see their pictures you understand that their works do not meet your expectations and requirements. In other words, the right choice of a wedding photographer is as important as the choice of a wedding gown. Thus, if you want to have quality pictures, depicting the true atmosphere of your wedding it is recommended to start looking for a professional photographer well in advance.
Most professional wedding photographers have websites where they describe the services they offer and demonstrate the samples of their works. Thus, start looking for your wedding photographer online. Never be in a hurry, because rush decisions may turn in to a huge disappointment and waste of money.
To make the right choice you will need to invest time in a decent online research. Take time to surf the Internet and to compare services offered by different photographers. While examining their portfolios, pay attention to the creativity and lightning exposure of the offered photos. If you like the pictures you can contact a photographer to get additional information about the services he/she offers and to discuss the details of the upcoming wedding.
About the Author
Before making a final decision you need to make sure you feel comfortable with the photographer and that he/she listens to what you want. To get more information about the photographer you consider hiring you may read customer reviews. It is also recommended visiting forums where people share their opinions and give helpful recommendations.
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Source: http://www.articlerich.com/Article/Reasons-to-Hire-a-Professional-Wedding-Photographer/2452429
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Magnesium oxide: From Earth to super-Earth
Friday, November 23, 2012
The mantles of Earth and other rocky planets are rich in magnesium and oxygen. Due to its simplicity, the mineral magnesium oxide is a good model for studying the nature of planetary interiors. New work from a team led by Carnegie's Stewart McWilliams studied how magnesium oxide behaves under the extreme conditions deep within planets and found evidence that alters our understanding of planetary evolution. It is published November 22 by Science Express.
Magnesium oxide is particularly resistant to changes when under intense pressures and temperatures. Theoretical predictions claim that it has just three unique states with different structures and properties present under planetary conditions: solid under ambient conditions (such as on the Earth's surface), liquid at high temperatures, and another structure of the solid at high pressure. The latter structure has never been observed in nature or in experiments.
McWilliams and his team observed magnesium oxide between pressures of about 3 million times normal atmospheric pressure (0.3 terapascals) to 14 million times atmospheric pressure (1.4 terapascals) and at temperatures reaching as high as 90,000 degrees Fahrenheit (50,000 Kelvin), conditions that range from those at the center of our Earth to those of large exo-planet super-Earths. Their observations indicate substantial changes in molecular bonding as the magnesium oxide responds to these various conditions, including a transformation to a new high-pressure solid phase.
In fact, when melting, there are signs that magnesium oxide changes from an electrically insulating material like quartz (meaning that electrons do not flow easily) to a metal similar to iron (meaning that electrons do flow easily through the material).
Drawing from these and other recent observations, the team concluded that while magnesium oxide is solid and non-conductive under conditions found on Earth in the present day, the early Earth's magma ocean might have been able to generate a magnetic field. Likewise, the metallic, liquid phase of magnesium oxide can exist today in the deep mantles of super-Earth planets, as can the newly observed solid phase.
"Our findings blur the line between traditional definitions of mantle and core material and provide a path for understanding how young or hot planets can generate and sustain magnetic fields," McWilliams said.
"This pioneering study takes advantage of new laser techniques to explore the nature of the materials that comprise the wide array of planets being discovered outside of our Solar System," said Russell Hemley, director of Carnegie's Geophysical Laboratory. "These methods allow investigations of the behavior of these materials at pressures and temperatures never before explored experimentally."
###
Carnegie Institution: http://www.ciw.edu
Thanks to Carnegie Institution for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/125444/Magnesium_oxide__From_Earth_to_super_Earth
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Temporary Full Time Teacher - Teaching Jobs in Canada - powered ...
Peace Wapiti School Division No. 76
Invites applications for:
Sexsmith Secondary School
Sexsmith, Alberta
Competition Number: 201211-033
Temporary Full Time Teacher
Senior High Math
(1.0 f.t.e.)
Effective: January 7, 2013 ? June 28, 2013
Qualifications:
* A Bachelors in Education
* Able to meet outside school hours
* Able to work as part of a team
* Willingness to participate in extracurricular activities would be an asset
Competition will remain open until a suitable candidate has been found
Human Resources Department
c/o Peace Wapiti School Division No.76
8611A ? 108 Street
Grande Prairie, AB T8V 4C5
Ph: (780) 532-8133 Fax (780) 532-4234
E-mail: resumes@pwsd76.ab.ca
Only candidates receiving interviews will be contacted
Please be advised that a current RCMP Criminal Records Check MUST be presented as a Condition of Employment
Source: http://jobsearch.educationcanada.com/index.phtml?a=v&j=118461
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Friday, November 23, 2012
Diet Robot, Autom, Now Available On IndieGogo, Will Ship In Six Months
Just in time for post-holiday guilt comes Autom, the diet robot that reminds you to eat healthy, asks you how much you exercised per day, and generally sits there being judgmental as you stuff your face with pecan pie. The robot, originally announced in 2007, is coming to live thanks to an Indiegogo campaign and the help of gadget masters PCH International, a manufacturer in Shenzhen, China.Source: http://feedproxy.google.com/~r/Techcrunch/~3/Sd65rncs5Ok/
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Taliban suicide bomber kills 23 in Pakistan
People look at dead bodies of a suicide attack victims, at a local hospital in Rawalpindi, Pakistan on Wednesday, Nov. 21, 2012. A suicide bomber had tried to enter a procession near a Shiite mosque, where the bomber detonated the explosives after being stopped by security forces killing or wounding scores of people, police officials said. (AP Photo/C.A. Hussain)
People look at dead bodies of a suicide attack victims, at a local hospital in Rawalpindi, Pakistan on Wednesday, Nov. 21, 2012. A suicide bomber had tried to enter a procession near a Shiite mosque, where the bomber detonated the explosives after being stopped by security forces killing or wounding scores of people, police officials said. (AP Photo/C.A. Hussain)
Pakistani hospital staff treat a person injured in a suicide attack on Shiite mourners in Rawalpindi, Pakistan on Wednesday, Nov. 21, 2012. A suicide bomber had tried to enter a procession near a Shiite mosque, where the bomber detonated the explosives after being stopped by security forces killing scores of people and left many wounded, police officials said. (AP Photo/C.A. Hussain)
A Pakistani mother holds her injured child at a local hospital in Karachi, Pakistan on Wednesday, Nov. 21, 2012. Two bombs exploded outside a Shiite mosque in the southern city of Karachi, killing scores of people and wounding others in a suicide attack, police official said. (AP Photo/Fareed Khan)
People rush an injured woman to an emergency ward of a local hospital in Karachi, Pakistan on Wednesday, Nov. 21, 2012. Two bombs exploded outside a Shiite mosque in the southern city of Karachi, killing scores of people and wounding others in a suicide attack, police official said. (AP Photo/Fareed Khan)
People run away after a second blast outside a Shiite mosque during a mourning congregation in Karachi, Pakistan on Wednesday, Nov. 21, 2012. Two bombs exploded outside a Shiite mosque in the southern city of Karachi, killing scores of people and wounding others in a suicide attack, police official said. (AP Photo/Shakil Adil)
ISLAMABAD (AP) ? A Taliban suicide bomber struck a Shiite Muslim procession near Pakistan's capital, killing 23 people in the latest of a series of bombings targeting Shiites during the holiest month of the year for the sect, officials said Thursday.
The bomber attacked the procession around midnight Wednesday in the city of Rawalpindi, located next to the capital, Islamabad, said Deeba Shahnaz, a state rescue official. At least 62 people were wounded by the blast, including six policemen. Eight of the dead and wounded were children, said Shahnaz.
Police tried to stop and search the bomber as he attempted to join the procession, but he ran past them and detonated his explosives, said senior police official Haseeb Shah. The attacker was also carrying grenades, some of which exploded, said Shah.
"I think the explosives combined with grenades caused the big loss," said Shah.
Local TV footage showed the scene of the bombing littered with body parts and smeared with blood. Shiites beat their heads and chests in anguish.
"It was like the world was ending," said one of the victims, Nasir Shah, describing the blast. He was being treated at a local hospital for wounds to his hands and legs.
Earlier Wednesday, the Taliban set off two bombs within minutes outside a Shiite mosque in the southern city of Karachi, killing at least one person and wounding several others, senior police official Javed Odho said.
Pakistani Taliban spokesman Ahsanullah Ahsan claimed responsibility for the attacks in Rawalpindi and Karachi.
"We have a war of belief with Shiites," Ahsan told The Associated Press by telephone from an undisclosed location. "They are blasphemers. We will continue attacking them."
The Sunni-Shiite schism over the true heir to Islam's Prophet Muhammad dates back to the seventh century.
Shiites are currently observing the holy month of Muharram. On Saturday, Shiites will observe the holiest day of the month, Ashoura, which commemorates the seventh century death of Imam Hussein, the Prophet Muhammad's grandson.
The country has a long history of sectarian violence carried out by both extremist Sunni and Shiite Muslims against the opposite sect. Most attacks in recent years have targeted Shiites, who make up a minority in the overwhelmingly Muslim country.
The Pakistani government increases security every Muharram to protect Shiites. But attacks regularly occur, and activists criticize the government for not doing enough to safeguard the minority sect.
____
Associated Press writer Rasool Dawar contributed to this report from Peshawar, Pakistan.
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Opera boss to become new BBC director-general
LONDON (Reuters) - The new BBC director-general is to be the current chief executive of the Royal Opera House, Tony Hall, BBC television news said on Thursday.
Hall, a former director of BBC news, will replace George Entwistle who resigned earlier this month after just 54 days after failing to get to grips with a child sex abuse scandal that has thrown the 90-year-old state-funded broadcaster into turmoil.
BBC Trust chairman Lord Patten said Hall was "the right person to lead the BBC out of its current crisis".
His journalism experience would be "invaluable as the BBC looks to rebuild its reputation", Patten added in a statement to staff quoted on the BBC's news website.
"The past eight weeks have been very traumatic for the BBC but this is a significant day ... (that) marks the beginning of a new phase.
"The key challenge will be re-establishing our reputation with the public. I hope you will all support Tony Hall as he goes about the important work of doing just that."
Hall is expected to take up his position in March.
(Reporting by Stephen Addison; editing by Tim Castle)
Source: http://news.yahoo.com/opera-boss-become-bbc-director-general-bbc-121738687.html
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Thursday, November 22, 2012
MintLife Blog | Personal Finance News & Advice | 6 Ways to Rework ...
Once you slide into the post-Thanksgiving food coma, the idea of reprising the meal loses just a bit of its luster. After a round of turkey-and-cranberry sandwiches on Black Friday, the remaining leftovers ? and yes, there are bound to be some ? look even less appealing.
We?ve had a few bright ideas?for repurposing Thanksgiving leftovers.
This year, we asked chefs, food bloggers and other experts for their best recipes to reinvent Thanksgiving leftovers. Six to try:
Candied Sweet Potato Soda
Portland restaurant The Original Dinerant makes this unique drink from scratch using sweet potatoes, marshmallows and other ingredients. You can also use leftover candied sweet potatoes in lieu of sweet potatoes.
Blend in a mixer, and then strain.?To make soda, add soda water to taste to three ounces of the puree. For a hot toddy, add an ounce of bourbon and hot water to taste.
Turkey Shepard?s Pie
?It?s one of my favorite leftover Turkey dishes besides the humble warm turkey sandwich, says Jason McLeod, executive chef of Consortium Holdings, whose San Diego, Calif., properties include Craft & Commerce, Neighborhood and Underbelly.
Start by shredding leftover turkey meat.?Chop leftover vegetables. Heat the turkey and vegetables in a large pot. Add leftover gravy and mix well.
Add your choice of seasoning ? McLeod uses chipotle powder, garlic powder and onion powder. Place the mix in casserole dish and cover with leftover mashed potatoes.
Bake in oven at 350 degrees for about 25 minutes. Serve with leftover cranberry sauce.
Basic Turkey Jerky
If you have a dehydrator, turn leftover turkey into a dried snack with this recipe from Excalibur Dehydrators.
Coat thin strips of turkey with a little olive oil and a few seasonings to taste.?Place strips on the dehydrator tray, making sure that they do not touch each other.
Set the temperature for 140 degrees. Cook 6 to 12 hours, checking hourly until the inside of a slice has no moisture at all and is the same color throughout.
Thanksgiving Eggs Benedict
Sullivan?s Steakhouse?in Austin, Texas, turns leftover turkey into a brunch standby.
To make, set aside two to four slices of turkey, a scoop of stuffing and an ounce or two of gravy per person. Heat each component in a microwave until?warm.
Split an English muffin per person and then toast. Scoop stuffing on top?of each side of the English muffin.?Top stuffing with slices of reheated turkey.
Bring two cups of water and a teaspoon white vinegar to a simmer in a small saucepot. Crack two?eggs, then drop into the simmering water and poach for 2-4 minutes.
Remove the eggs with a slotted spoon and drain on a paper towel. Set an egg on top of each muffin half.
Ladle gravy over each poached egg.?Spoon a little cranberry sauce on the plate.
Candied Yam Bread Pudding
No pumpkin pie left? No problem. Chef Derek Simcik, executive chef of Chicago?s Atwood Caf?, makes a dessert from leftover sweet potatoes and bread.
First, butter a deep pan. Tear 12 ounces of leftover bread into chunks and place in a large bowl. Pour a quart of heavy cream over the bread and set aside until soft.
Beat three eggs and five ounces sugar until smooth and thick. Add a half-ounce of vanilla, an ounce of melted butter, and two ounces of brandy.
Gently toss together the egg mixture, the bread and four to five ounces of candied yams. Pour into pan and bake at 350 until browned and almost set, about 45 minutes.
Thanksgiving Monte Cristo
?For a lighter version, pan fry this recipe instead of deep-frying,? says Katherine Humphus, executive chef of BO-beau kitchen + bar and100 Wines Hillcrest in San Diego, Calif.
To make, form two patties out of leftover stuffing, with gravy mixed in for moisture. Make a sandwich using the stuffing patties as ?bread,? placing turkey, mashed potatoes and some green bean casserole in between.
Close patties around the filling. Bread each with flour and egg. Deep fry until golden brown and hot in the center, and enjoy with side of cranberry sauce.
Frugal Foodie is a journalist based in New York City who spends her days writing about personal finance and obsessing about what she?ll have for dinner. Chat with her on Twitter through @MintFoodie.
?
Source: http://www.mint.com/blog/how-to/6-ways-to-rework-those-thanksgiving-dinner-leftovers-1112/
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How To Get Rihanna's Rockin' Body | Lucille Roberts Blog
It seems everyone has Rihanna-fever, and it?s easy to see why. Between her catchy hit songs and fabulously fit body, we?re all crushing hard on the songstress from Barbados.
Rihanna is not shy about showing off her curves, and who would be after all the hard work she puts in to keep her body in tip-top shape. She exercises every chance she gets and eats the right foods to fuel her body, staying as dedicated to her health and fitness as she is with her music.
We?ve got the exercises and diet tips inspired by Ri-Ri that will transform your body from flab to fab!
Engaging multiple muscle groups with one exercise is important for a singer who?s constantly on the road and pressed for time. Try these 4 exercises for an all-over calorie burn that will tighten and tone every muscle.
Curtsy Lunge
- Begin standing with feet hip-width apart, a dumbbell in your left hand.
- Step your left leg behind you and to the right, as if you are doing a curtsy, and lower into a lunge.
- At the same time, raise your left arm up so that it is parallel to the floor, in line with your shoulder.
- Return to start position and repeat on same leg.
- Do 3 sets for each leg, 10 reps each.
?
?
Jack Knife
- Begin by kneeling on the ground with a stability ball behind you.
- Slowly come up to the top of a pushup position with your shins resting on the top of the ball.
- Keeping your abs tight throughout the move, tuck your knees toward your chest and roll the ball forward.
- Slowly roll back to the start position, not letting your back sag, and repeat.
- Do 3 sets of 10 reps.
.
Dumbbell Step Up?
- Begin by standing in front of a workout bench or platform, a dumbbell in each hand.
- Place right foot on top of the bench, and pushing through your heel, step up on the platform.
- Avoid having your left foot come down when standing on the bench.
- Slowly lower your left leg back down to the ground, but keep your right foot planted on the bench.
- Repeat the exercise on the same leg, then switch when the set is done.
- Do 3 sets of 12 reps for each leg.
Overhead Triceps Extension on Stability Ball
- Begin by grabbing a weighted bar with a shoulder-width overhand grip.
- Sit upright on a stability ball, feet flat on the floor and knees bent at a 90 degree angle.
- Hold the bar at arm?s length, extended above your head.
- Keeping arms still, bend at the elbows and lower the bar behind your head until forearms are parallel to the floor.
- Bring arms back to start position.
- Do 3 sets of 12 reps.
Rihanna?s Healthy Eating & Diet Tips
thestyleandbeautydoctor.com
Rihanna has been working with celebrity personal trainer Harley Pasternak and follows his Five Factor diet plan. Instead of the traditional three meals a day, Pasternak suggests eating 5 small meals throughout the course of the day.
Each of these meals must have five essential components: protein, fiber, healthy carbs (fruits and vegetables), a healthy fat (avocado, nuts etc.), and a sugar-free drink such as water or tea.
On the Five Factor plan, dieters are also allowed a ?cheat day? once a week. Pasternak says the cheat day helps keep his clients on track with the health and fitness goals.
In an interview with Fabulous magazine, Rihanna revealed what she would eat in a typical day:
?I have egg whites and pineapple for breakfast with hot water and lemon. For lunch I have fish and potatoes. I hate vegetables but I make myself eat them. For dinner I have fish again.?
Overall, Rihanna tries to stay away from refined carbohydrates and red meat to maintain her 133 pound figure. But does size matter to this sexy singer? ?My size varies,? she told Fabulous magazine, ?sometimes I?m a 2, sometimes 4 ? but what matters is being fit and healthy.?
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Short DNA strands in the genome may be key to understanding human cognition and diseases
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Public release date: 21-Nov-2012[ | E-mail |
Share ] Contact: Mount Sinai Press Office
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The Mount Sinai Hospital / Mount Sinai School of Medicine
Previously discarded, human-specific 'junk' DNA represents untapped resource in the study of diseases like Alzheimer's and autism
Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. The findings are published in the November 20th issue of PLoS Biology.
There are nearly 40 million positions in the human genome with DNA sequences that are different than those in non-human primates, making the task of learning which are important and which are inconsequential a challenge for scientists. Rather than comparing these sequences strand by strand, Schahram Akbarian, MD, PhD, Professor of Psychiatry and Neuroscience at Mount Sinai School of Medicine, wanted to identify the crucial set of differences between the two genomes by looking more broadly at the chromatin, the structure that packages the DNA and controls how it is expressed.
They found hundreds of regions throughout the human genome which showed a markedly different chromatin structure in neurons in the prefrontal cortex, a brain region that controls complex emotional and cognitive behavior, compared to non-human primates. The findings of the study provide important insights for diseases that are unique to humans such as Alzheimer's disease and autism.
"While mapping the human genome has taught us a great deal about human biology, the emerging field of epigenomics may help us identify previously overlooked or discarded sequences that are key to understanding disease," said Dr. Akbarian. "We identified hundreds of loci that represent untapped areas of study that may have therapeutic potential."
Dr. Akbarian and his research team isolated small snippets of chromatin fibers from the prefrontal cortex. Next, they analyzed these snippets to determine what genetic signals they were expressing. Many of the sequences with human-specific epigenetic characteristics were, until recently, considered to be "junk DNA" with no particular function.
Now, they present new leads on how the human brain has evolved, and a starting point for studying neurological diseases. For example, the sequence of DPP10a gene critically important for normal human brain developmentnot only showed distinct human-specific chromatin structures different from other primate brains such as the chimpanzee or the macaque, but the underlying DNA sequence showed some interesting differences from two extinct primatesthe Neanderthal and Denisovan, most closely related to our own species and also referred to as 'archaic hominins'.
"Many neurological disorders are unique to human and are very hard as a clinical syndrome to study in animals, such as Alzheimer's disease, autism, and depression," said Dr. Akbarian. "By studying epigenetics we can learn more about those unique pieces of the human genome."
The research team also discovered that several of these chromatin regions appear to physically interact with each other inside the cell nucleus, despite being separated by hundreds of thousands of DNA strands on the genome. This phenomenon of "chromatin looping" appears to control the expression of neighboring genes, including several with a critical role for human brain development.
"There is growing consensus among genome researchers that much of what was previously considered as 'junk sequences' in our genomes indeed could play some sort of regulatory role," said Dr. Akbarian.
This study was supported by grants from the National Institutes of Health. Dr. Akbarian plans to do more epigenetic studies in other areas of the brain to see if there are additional chromatin regions that are unique to humans. They also plan to study the epigenomes of other mammals with highly evolved social behaviors such as elephants.
Dr. Akbarian joined Mount Sinai in July 2012. He is internationally known for his cutting-edge research on the epigenetic mechanisms of psychiatric disorders. He is a widely recognized expert in advanced chromatin toolsmany of which were developed in his laboratoryin conjunction with mouse mutagenesis and behavioral models of mental illness to bridge molecular, cellular, and behavioral investigations. He is also a renowned authority on the epigenetic analysis of human brain tissue examined postmortem.
Prior to joining Mount Sinai, Dr. Akbarian was Director of the Brudnick Neuropsychiatric Research Institute. He received his medical and doctorate degrees from the Freie Universitaet Berlin. Dr. Akbarian completed his postdoctoral training in neuroscience at the University of California at Irvine and the Whitehead Institute, and his residency in psychiatry at Massachusetts General Hospital.
###
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of the leading medical schools in the United States. The Medical School is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by US News and World Report.
The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2011, US News and World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and US News and World Report and whose hospital is on the US News and World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.
For more information, visit http://www.mountsinai.org/.
Find Mount Sinai on:
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[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 21-Nov-2012[ | E-mail |
Share ] Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Previously discarded, human-specific 'junk' DNA represents untapped resource in the study of diseases like Alzheimer's and autism
Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. The findings are published in the November 20th issue of PLoS Biology.
There are nearly 40 million positions in the human genome with DNA sequences that are different than those in non-human primates, making the task of learning which are important and which are inconsequential a challenge for scientists. Rather than comparing these sequences strand by strand, Schahram Akbarian, MD, PhD, Professor of Psychiatry and Neuroscience at Mount Sinai School of Medicine, wanted to identify the crucial set of differences between the two genomes by looking more broadly at the chromatin, the structure that packages the DNA and controls how it is expressed.
They found hundreds of regions throughout the human genome which showed a markedly different chromatin structure in neurons in the prefrontal cortex, a brain region that controls complex emotional and cognitive behavior, compared to non-human primates. The findings of the study provide important insights for diseases that are unique to humans such as Alzheimer's disease and autism.
"While mapping the human genome has taught us a great deal about human biology, the emerging field of epigenomics may help us identify previously overlooked or discarded sequences that are key to understanding disease," said Dr. Akbarian. "We identified hundreds of loci that represent untapped areas of study that may have therapeutic potential."
Dr. Akbarian and his research team isolated small snippets of chromatin fibers from the prefrontal cortex. Next, they analyzed these snippets to determine what genetic signals they were expressing. Many of the sequences with human-specific epigenetic characteristics were, until recently, considered to be "junk DNA" with no particular function.
Now, they present new leads on how the human brain has evolved, and a starting point for studying neurological diseases. For example, the sequence of DPP10a gene critically important for normal human brain developmentnot only showed distinct human-specific chromatin structures different from other primate brains such as the chimpanzee or the macaque, but the underlying DNA sequence showed some interesting differences from two extinct primatesthe Neanderthal and Denisovan, most closely related to our own species and also referred to as 'archaic hominins'.
"Many neurological disorders are unique to human and are very hard as a clinical syndrome to study in animals, such as Alzheimer's disease, autism, and depression," said Dr. Akbarian. "By studying epigenetics we can learn more about those unique pieces of the human genome."
The research team also discovered that several of these chromatin regions appear to physically interact with each other inside the cell nucleus, despite being separated by hundreds of thousands of DNA strands on the genome. This phenomenon of "chromatin looping" appears to control the expression of neighboring genes, including several with a critical role for human brain development.
"There is growing consensus among genome researchers that much of what was previously considered as 'junk sequences' in our genomes indeed could play some sort of regulatory role," said Dr. Akbarian.
This study was supported by grants from the National Institutes of Health. Dr. Akbarian plans to do more epigenetic studies in other areas of the brain to see if there are additional chromatin regions that are unique to humans. They also plan to study the epigenomes of other mammals with highly evolved social behaviors such as elephants.
Dr. Akbarian joined Mount Sinai in July 2012. He is internationally known for his cutting-edge research on the epigenetic mechanisms of psychiatric disorders. He is a widely recognized expert in advanced chromatin toolsmany of which were developed in his laboratoryin conjunction with mouse mutagenesis and behavioral models of mental illness to bridge molecular, cellular, and behavioral investigations. He is also a renowned authority on the epigenetic analysis of human brain tissue examined postmortem.
Prior to joining Mount Sinai, Dr. Akbarian was Director of the Brudnick Neuropsychiatric Research Institute. He received his medical and doctorate degrees from the Freie Universitaet Berlin. Dr. Akbarian completed his postdoctoral training in neuroscience at the University of California at Irvine and the Whitehead Institute, and his residency in psychiatry at Massachusetts General Hospital.
###
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of the leading medical schools in the United States. The Medical School is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by US News and World Report.
The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2011, US News and World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and US News and World Report and whose hospital is on the US News and World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.
For more information, visit http://www.mountsinai.org/.
Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter: @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy
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Source: http://www.eurekalert.org/pub_releases/2012-11/tmsh-sds112112.php
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